How Quelm turns biology into decision support
Six integrated layers are designed to process multi-source biological data into clinical decision support. Every algorithm is built against peer-reviewed science and established clinical guidelines. Validation is ongoing.
Research foundation
Built on established peer-reviewed science and clinical guidelines.
Clinical Pharmacogenetics Implementation Consortium (CPIC)
Evidence-based guidelines for gene-drug pairs. Peer-reviewed, freely available.
AHA/ACC Guidelines + CredibleMeds QTc Database
QTc prolongation risk classification. Drug-induced arrhythmia prevention protocols.
ISO 15197 + ADA Standards of Care
Glucose monitoring accuracy standards. Metabolic health assessment frameworks.
BDNF/MMSE Literature + Psychedelic Research Corpus
Neuroplasticity biomarkers. Treatment response prediction models.
System architecture
Multi-source inputs flow through six processing domains into clinical decision support.
Pharmacogenomics
BUILTMetabolic Intelligence
BUILTCardiac Safety
BUILTBehavioral AI Coaching
BUILTDigital Twin Simulation
BUILTPrivacy Architecture
BUILTValidation pipeline
Four-stage pathway from algorithmic validation to regulatory approval.
Internal testing against established clinical guidelines (CPIC, AHA/ACC, ISO 15197). Formula verification, edge-case coverage, safety gate testing.
IRB-approved observational study with partner clinics. Outcome tracking for PGx dosing accuracy, metabolic predictions, and cardiac safety alerts.
Controlled prospective trial. 500+ participants. Primary endpoints: adverse event reduction, treatment adherence, patient-reported outcomes.
FDA 510(k) for clinical decision support. Clinical evidence package compilation. Post-market surveillance framework.
Safety protocols
Patient safety is architecturally enforced, not bolted on.
Cardiac Pre-Screening Gate
Multi-gate qualification pipeline designed to ensure cardiac safety clearance before treatment. Includes QTc, electrolyte, and CYP2D6 checks.
PGx Drug Interaction Check
Medication protocols are designed to run through pharmacogenomic interaction analysis. CYP enzyme metabolizer status is used to inform safe dosing ranges.
Multi-Gate Qualification
Physiological, psychological, and social readiness assessed independently. All gates are designed to pass before enrollment proceeds.
Federated Privacy
PHI never leaves the device for model training. Differential privacy budgets enforce mathematical guarantees on re-identification risk.
Clinician Override
Every AI recommendation can be overridden by a licensed clinician. The system supports clinical judgment — it does not replace it.
Quelm is a decision support platform. It does not make diagnostic claims. All recommendations are subject to clinician review and patient consent.
Work with us
Three tracks for clinical partners, researchers, and advisors.
Scientific Advisory Board
Shape research direction, validate clinical algorithms, co-author publications.
Clinical Pilot Partner
Integrate Quelm into your practice. Access clinician dashboard and patient monitoring tools.
Research Data Collaboration
Access de-identified federated insights for population health research and clinical trials.